\u4e00\u6b21\u770b\u4f3c\u5bfb\u5e38\u7684\u201c\u9c7c\u523a\u624e\u624b\u201d\uff0c\u5374\u53ef\u80fd\u9690\u85cf\u7740\u8db3\u4ee5\u81f4\u547d\u7684\u5371\u673a\uff01<\/p>\n
\u8fd1\u65e5(4\u670830\u65e5)\uff0c\u4e0a\u6d77\u5e02\u7b2c\u516d\u4eba\u6c11\u533b\u9662\u516c\u5e03\u4e86\u4e00\u5219\u75c5\u4f8b\uff1a<\/p>\n
\u65e9\u524d\uff0c\u8be5\u9662\u611f\u67d3\u75c5\u79d1\u6536\u6cbb\u4e86\u4e00\u4f8b\u56e0\u9c7c\u523a\u523a\u4f24\u5bfc\u81f4\u521b\u4f24\u5f27\u83cc\u611f\u67d3\u7684\u5371\u91cd\u75c5\u4f8b\u3002\u60a3\u8005\u5728\u5904\u7406\u6d77\u4ea7\u54c1\u65f6\u4e0d\u614e\u88ab\u9c7c\u523a\u624e\u4f24\u5de6\u624b\u4e2d\u6307\uff0c\u75c5\u60c5\u572824\u5c0f\u65f6\u5185\u6025\u5267\u6076\u5316\uff0c\u7ecf\u591a\u5b66\u79d1\u534f\u4f5c\u6551\u6cbb\u540e\u8f6c\u5371\u4e3a\u5b89\u3002<\/p>\n
\u4e00\u6b21\u758f\u5ffd\uff1a<\/strong><\/p>\n \u6307\u5c16\u4e0a\u7684\u201c\u9690\u5f62\u6740\u624b\u201d<\/strong><\/p>\n 3\u670816\u65e5\uff0c70\u591a\u5c81\u7684\u674e\u963f\u59e8(\u5316\u540d)\u5728\u5904\u7406\u6d77\u4ea7\u54c1\u65f6\u4e0d\u614e\u88ab\u9c7c\u523a\u624e\u4f24\u4e86\u5de6\u624b\u4e2d\u6307\u3002\u8d77\u521d\uff0c\u5979\u53ea\u662f\u7b80\u5355\u51b2\u6d17\u6d88\u6bd2\uff0c\u5e76\u672a\u91cd\u89c6\u3002<\/p>\n \u53ef\u4ec5\u4ec5\u8fc7\u4e86\u4e00\u5929\uff0c\u60c5\u51b5\u5c31\u6025\u8f6c\u76f4\u4e0b\uff1a\u5de6\u624b\u50cf\u5145\u4e86\u6c14\u4e00\u6837\u8fc5\u901f\u80bf\u80c0\uff0c\u75bc\u75db\u94bb\u5fc3\uff0c\u7ea2\u80bf\u987a\u7740\u624b\u6307\u4e00\u8def\u8513\u5ef6\u5230\u4e86\u624b\u8155\u3002\u6b21\u65e5\u674e\u963f\u59e8\u51fa\u73b0\u9ad8\u70ed\uff0c\u4f53\u6e29\u6700\u9ad8\u81f339.7\u2103\u3002<\/p>\n \u5bb6\u5c5e\u7d27\u6025\u9001\u533b\u540e\uff0c\u8840\u5e38\u89c4\u663e\u793a\u767d\u7ec6\u80de\u5347\u523016.03\u00d710\u2079\/L\uff0c\u708e\u75c7\u6307\u6807\u660e\u663e\u5347\u9ad8\uff0c\u7d27\u6025\u6536\u6cbb\u81f3\u611f\u67d3\u75c5\u79d1\u3002<\/p>\n \u53cc\u91cd\u8003\u9a8c\uff1a<\/strong><\/p>\n \u57fa\u7840\u75c5\u7f20\u8eab\u7684\u201c\u9ad8\u5371\u65f6\u523b\u201d<\/strong><\/p>\n \u5165\u9662\u540e\uff0c\u611f\u67d3\u75c5\u79d1\u56e2\u961f\u8be6\u7ec6\u8be2\u95ee\u75c5\u53f2\uff0c\u4e86\u89e3\u5230\u674e\u963f\u59e8\u66fe\u7ecf\u63a5\u89e6\u8fc7\u6d77\u9c7c\uff0c\u5e76\u4e14\u4f24\u53e3\u80bf\u80c0\u8fdb\u5c55\u5341\u5206\u8fc5\u901f\uff0c\u9ad8\u5ea6\u6000\u7591\u4e3a\u521b\u4f24\u5f27\u83cc\u3002\u8fd9\u7c7b\u75c5\u539f\u83cc\u6781\u4e3a\u51f6\u9669\uff0c\u75c5\u60c5\u8fdb\u5c55\u8fc5\u901f\uff0c\u4e25\u91cd\u8005\u9700\u622a\u80a2\u3002\u63a5\u8bca\u533b\u751f\u7acb\u5373\u542f\u52a8\u5e94\u6025\u9884\u6848\uff0c\u7ecf\u9a8c\u6027\u7ed9\u4e88\u5934\u5b62\u54cc\u916e\u8212\u666e\u6df1\u8054\u5408\u5de6\u6c27\u6c1f\u6c99\u661f\u6297\u611f\u67d3\u6cbb\u7597\uff0c\u5373\u523b\u8bf7\u9aa8\u79d1\u4f1a\u8bca\u8bc4\u4f30\u624b\u672f\u6307\u5f81\u3002<\/p>\n \u674e\u963f\u59e8\u7684\u75c5\u60c5\u4e4b\u6240\u4ee5\u68d8\u624b\uff0c\u4e0d\u4ec5\u662f\u56e0\u4e3a\u611f\u67d3\u51f6\u731b\uff0c\u66f4\u56e0\u4e3a\u5979\u662f\u4e00\u4f4d\u5fc3\u810f\u74e3\u819c\u7f6e\u6362\u53ca\u8d77\u640f\u5668\u690d\u5165\u672f\u540e\u7684\u60a3\u8005\uff0c\u957f\u671f\u670d\u7528\u6297\u51dd\u836f\uff1b\u540c\u65f6\u5408\u5e76\u7cd6\u5c3f\u75c5\uff0c\u5165\u9662\u65f6\u5df2\u51fa\u73b0\u7cd6\u5c3f\u75c5\u916e\u75c7\u3002<\/p>\n \u201c\u91cd\u75c7\u611f\u67d3+\u5fc3\u810f\u75c5+\u7cd6\u5c3f\u75c5\u916e\u75c7\u201d\u4e09\u8005\u53e0\u52a0\uff0c\u75c5\u60c5\u5371\u91cd\uff0c\u6781\u6613\u5f15\u53d1\u8113\u6bd2\u6027\u4f11\u514b\u6216\u5fc3\u8870\u3002<\/p>\n<\/p>\n \u60a3\u8005\u624b\u90e8\u80bf\u80c0\u660e\u663e\uff0c\u5ef6\u53ca\u624b\u8155\uff0c\u624b\u6307\u5c40\u90e8\u51fa\u73b0\u6c34\u75b1\u3002<\/p>\n \u751f\u6b7b\u62a2\u6551\uff1a<\/strong><\/p>\n \u591a\u5b66\u79d1\u56e2\u961f\u201c\u62a2\u56de\u624b\u6307\u201d<\/strong><\/p>\n \u9aa8\u79d1\u4e0e\u611f\u67d3\u75c5\u79d1\u5171\u540c\u8bc4\u4f30\u540e\uff0c\u51b3\u5b9a\u5c3d\u5feb\u624b\u672f\u5207\u5f00\u51cf\u538b\u3001\u5f15\u6d41\u30023\u670819\u65e5\uff0c\u674e\u963f\u59e8\u63a5\u53d7\u4e86\u5de6\u624b\u6e05\u521b\u53ca\u5207\u5f00\u5f15\u6d41\u672f\u3002\u9488\u5bf9\u521b\u4f24\u5f27\u83cc\u611f\u67d3\u6613\u51fa\u73b0\u7ec4\u7ec7\u574f\u6b7b\u8fdb\u5c55\u7684\u7279\u70b9\uff0c\u672f\u540e\u56e2\u961f\u5bc6\u5207\u76d1\u6d4b\u4f24\u53e3\u60c5\u51b5\u3002\u7531\u4e8e\u611f\u67d3\u8303\u56f4\u8f83\u5e7f\uff0c\u6309\u8bca\u7597\u89c4\u8303\u4e8e3\u670826\u65e5\u518d\u6b21\u884c\u6e05\u521b\u672f\uff0c\u6e05\u695a\u6b8b\u4f59\u574f\u6b7b\u7ec4\u7ec7\uff0c\u5e76\u653e\u7f6eVSD\u8d1f\u538b\u5f15\u6d41\u88c5\u7f6e\u3002\u533b\u751f\u5c06\u672f\u4e2d\u7684\u7ec4\u7ec7\u6db2\u9001\u68c0\u5b8f\u57fa\u56e0\u68c0\u6d4b(NGS\u68c0\u6d4b)\u3002\u6b21\u65e5\u7ed3\u679c\u56de\u62a5\uff0c\u652f\u6301\u6700\u521d\u7684\u5224\u65ad\u2014\u2014\u521b\u4f24\u5f27\u83cc(Vibrio vulnificus)\uff0c\u5e8f\u5217\u6570\u9ad8\u8fbe\u5341\u51e0\u4e07\u6761\u3002\u6839\u636e\u75c5\u539f\u5b66\uff0c\u56e2\u961f\u4f7f\u7528\u5934\u5b62\u54cc\u916e\u94a0\u8212\u5df4\u5766\u94a0+\u5de6\u6c27\u6c1f\u6c99\u661f\u8054\u5408\u6297\u611f\u67d3\u3002<\/p>\n \u9274\u4e8e\u674e\u963f\u59e8\u6709\u673a\u68b0\u74e3\u819c\u7f6e\u6362\u53f2\uff0c\u957f\u671f\u5403\u534e\u6cd5\u6797\u6297\u51dd\uff0c\u672f\u524d\u505c\u7528\uff0c\u4f4f\u9662\u671f\u95f4\u5bc6\u5207\u76d1\u6d4bINR\u6307\u6807\uff0c\u52a8\u6001\u8c03\u6574\u6297\u51dd\u65b9\u6848\u3002\u540c\u65f6\uff0c\u8bf7\u5185\u5206\u6ccc\u4ee3\u8c22\u79d1\u534f\u540c\u8bca\u6cbb\uff0c\u4e88\u80f0\u5c9b\u7d20\u6cf5\u63a7\u5236\u9ad8\u8840\u7cd6\uff0c\u5e76\u8fdb\u884c\u6d88\u916e\u6cbb\u7597\u3002<\/p>\n<\/p>\n \u672f\u4e2d\u8113\u6db2\u9001\u68c0mNGS\u68c0\u6d4b\u3002<\/p>\n \u7ecf\u8fc72\u5468\u594b\u6218\uff0c\u674e\u963f\u59e8\u7684\u4f53\u6e29\u6062\u590d\u6b63\u5e38\uff0c\u5de6\u624b\u80bf\u80c0\u6d88\u9000\uff0c\u708e\u75c7\u6307\u6807\u9010\u6b65\u4e0b\u964d\uff0c\u8840\u7cd6\u7a33\u5b9a\uff0c\u6700\u7ec8\u8131\u79bb\u5371\u9669\u5e76\u51fa\u9662\u3002<\/p>\n<\/p>\n \u672f\u540e\u5207\u53e3\u5e72\u71e5\uff0c\u6108\u5408\u826f\u597d\uff0c\u624b\u80cc\u80bf\u80c0\u660e\u663e\u6d88\u9000\u3002<\/p>\n \u79d1\u666e\u5c0f\u77e5\u8bc6<\/strong><\/p>\n \u521b\u4f24\u5f27\u83cc\u88ab\u79f0\u4e3a\u201c\u6d77\u6d0b\u4e2d\u7684\u65e0\u60c5\u6740\u624b\u201d\u6216\u201c\u98df\u8089\u83cc\u201d\uff0c\u5e38\u5bc4\u751f\u5728\u7261\u86ce\u3001\u868c\u7c7b\u7b49\u6d77\u9c9c\u4e2d\u3002\u4e00\u65e6\u901a\u8fc7\u4f24\u53e3\u8fdb\u5165\u4eba\u4f53\uff0c\u8d77\u75c5\u6025\u3001\u8fdb\u5c55\u5feb\uff0c\u5982\u679c\u4e0d\u53ca\u65f6\u5904\u7406\uff0c48\u5c0f\u65f6\u5185\u6b7b\u4ea1\u7387\u8d85\u8fc750%\uff0c\u8d85\u8fc772\u5c0f\u65f6\u672a\u6cbb\u7597\u6b7b\u4ea1\u7387\u63a5\u8fd1100%\u3002\u56e0\u6b64\uff0c\u63d0\u9ad8\u9632\u8303\u610f\u8bc6\u3001\u53ca\u65f6\u5c31\u533b\u81f3\u5173\u91cd\u8981\u3002<\/p>\n 1.\u57fa\u672c\u7279\u6027<\/strong><\/p>\n \u5c5e\u4e8e\u5f27\u83cc\u79d1\uff0c\u9769\u5170\u6c0f\u9634\u6027\u83cc\uff0c\u5448\u68d2\u72b6\u6216\u5f27\u72b6\uff0c\u6709\u5355\u6781\u7aef\u97ad\u6bdb\uff0c\u80fd\u5728\u6c34\u4e2d\u72ec\u7acb\u751f\u5b58\u3002\u55dc\u76d0\u3001\u55dc\u6e29\uff0c\u9002\u5b9c\u7e41\u6b96\u6e29\u5ea6\u4e3a20\u2103-30\u2103\uff0c\u76d0\u5ea60\u2030-18\u2030\uff0c\u6c34\u6e29\u4f4e\u4e8e13\u2103\u65f6\u8fdb\u5165\u4f11\u7720\u671f\u3002\u5e38\u5bc4\u751f\u4e8e\u8d1d\u7c7b\u3001\u9c7c\u3001\u867e\u3001\u87f9\u7b49\u6d77\u6d0b\u751f\u7269\u8868\u9762\uff0c\u5c24\u5176\u559c\u6b22\u9c7c\u7c7b\u7684\u9ccd\u3001\u5c3e\u7b49\u5c16\u9510\u90e8\u4f4d\u3002<\/p>\n 2.\u611f\u67d3\u9014\u5f84<\/strong><\/p>\n \u4f24\u53e3\u611f\u67d3\uff1a\u76ae\u80a4\u6709\u7834\u635f(\u5982\u5212\u4f24\u3001\u523a\u4f24)\u65f6\uff0c\u63a5\u89e6\u542b\u521b\u4f24\u5f27\u83cc\u7684\u6d77\u6c34\u6216\u6d77\u4ea7\u54c1\uff0c\u7ec6\u83cc\u901a\u8fc7\u4f24\u53e3\u4fb5\u5165\u4eba\u4f53\u3002<\/p>\n \u7ecf\u53e3\u611f\u67d3\uff1a\u98df\u7528\u672a\u716e\u719f\u6216\u751f\u7684\u53d7\u6c61\u67d3\u6d77\u9c9c\uff0c\u5c24\u5176\u662f\u8d1d\u7c7b(\u5982\u7261\u86ce\u3001\u86e4\u870a)\uff0c\u7ec6\u83cc\u7ecf\u6d88\u5316\u9053\u8fdb\u5165\u4f53\u5185\u3002<\/p>\n 3.\u75c7\u72b6\u8868\u73b0<\/strong><\/p>\n \u4f24\u53e3\u611f\u67d3\u578b\uff1a\u521d\u671f\u4f24\u53e3\u5468\u56f4\u7ea2\u80bf\u3001\u75bc\u75db\uff0c\u8fc5\u901f\u53d1\u5c55\u4e3a\u6c34\u75b1\u3001\u8840\u75b1\uff0c\u76ae\u80a4\u5448\u9ed1\u7d2b\u8272\uff0c\u53ef\u8513\u5ef6\u81f3\u80a2\u4f53\u5176\u4ed6\u90e8\u4f4d\uff0c\u4e25\u91cd\u65f6\u51fa\u73b0\u808c\u8089\u574f\u6b7b\u3001\u574f\u75bd\u3002<\/p>\n \u8113\u6bd2\u75c7\u578b\uff1a\u611f\u67d3\u540e24-48\u5c0f\u65f6\u5185\u51fa\u73b0\u9ad8\u70ed\u3001\u5bd2\u6218\u3001\u4f4e\u8840\u538b\u3001\u795e\u5fd7\u6a21\u7cca\u7b49\u75c7\u72b6\uff0c\u53ef\u80fd\u8fc5\u901f\u8fdb\u5c55\u4e3a\u591a\u5668\u5b98\u529f\u80fd\u8870\u7aed\u3002<\/p>\n \u80c3\u80a0\u708e\u578b\uff1a\u98df\u7528\u6c61\u67d3\u6d77\u9c9c\u540e\u51fa\u73b0\u8179\u75db\u3001\u8179\u6cfb\u3001\u5455\u5410\u3001\u53d1\u70ed\u7b49\u6d88\u5316\u9053\u75c7\u72b6\uff0c\u4e00\u822c\u8f83\u8f7b\uff0c\u4f46\u514d\u75ab\u529b\u4f4e\u4e0b\u8005\u53ef\u80fd\u8f6c\u4e3a\u91cd\u75c7\u3002<\/p>\n 4.\u9ad8\u5371\u4eba\u7fa4<\/strong><\/p>\n \u6162\u6027\u809d\u75c5\u60a3\u8005(\u5982\u809d\u786c\u5316\u3001\u9152\u7cbe\u6027\u809d\u75c5)\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u3001\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u8005(\u5982\u957f\u671f\u4f7f\u7528\u514d\u75ab\u6291\u5236\u5242\u3001\u827e\u6ecb\u75c5\u60a3\u8005)\u3001\u957f\u671f\u55dc\u9152\u8005\u3001\u8001\u5e74\u4eba\u7b49\uff0c\u611f\u67d3\u540e\u75c5\u60c5\u66f4\u6613\u6076\u5316\uff0c\u6b7b\u4ea1\u7387\u8f83\u9ad8\u3002<\/p>\n 5.\u6e29\u99a8\u63d0\u793a<\/strong><\/p>\n \u5904\u7406\u6d77\u9c9c\u65f6\u8bf7\u52a1\u5fc5\u4f69\u6234\u6a61\u80f6\u539a\u624b\u5957\uff0c\u907f\u514d\u76ae\u80a4\u88ab\u523a\u4f24\uff1b<\/p>\n \u6d77\u9c9c\u5f7b\u5e95\u716e\u719f\u540e\u98df\u7528\uff0c\u907f\u514d\u751f\u98df\u6216\u534a\u751f\u98df\uff1b<\/p>\n \u6709\u4f24\u53e3\u65f6\u907f\u514d\u63a5\u89e6\u6d77\u6c34\u6216\u6d77\u4ea7\u54c1\uff1b<\/p>\n \u82e5\u88ab\u523a\u4f24\u6216\u98df\u7528\u6d77\u9c9c\u540e\u51fa\u73b0\u7ea2\u80bf\u3001\u53d1\u70ed\u3001\u8179\u75db\u7b49\u75c7\u72b6\uff0c\u7acb\u5373\u7528\u6e05\u6c34\u51b2\u6d17\u4f24\u53e3\uff0c\u7528\u7898\u4f0f\u6216\u9152\u7cbe\u6d88\u6bd2\uff0c\u8bf7\u7b2c\u4e00\u65f6\u95f4\u524d\u5f80\u533b\u9662\uff0c\u5e76\u4e3b\u52a8\u544a\u77e5\u533b\u751f\u6d77\u6c34\u6216\u6d77\u9c9c\u63a5\u89e6\u53f2\uff1b<\/p>\n \u60a3\u6709\u7cd6\u5c3f\u75c5\u3001\u6162\u6027\u809d\u75c5\u6216\u514d\u75ab\u529b\u4f4e\u4e0b\u7684\u4eba\u7fa4\uff0c\u66f4\u5bb9\u6613\u611f\u67d3\u521b\u4f24\u5f27\u83cc\uff0c\u66f4\u5e94\u52a0\u5f3a\u9632\u62a4\u3002<\/p>\n \u5982\u679c\u60a8\u6216\u60a8\u7684\u5bb6\u4eba\u5728\u5904\u7406\u6d77\u9c9c\u540e\u611f\u5230\u4e0d\u9002\uff0c\u8bf7\u7b2c\u4e00\u65f6\u95f4\u524d\u5f80\u6b63\u89c4\u533b\u9662\u5c31\u8bca\u3002\u65e9\u53d1\u73b0\u3001\u65e9\u8bca\u65ad\u3001\u65e9\u6cbb\u7597\uff0c\u662f\u5bf9\u6297\u521b\u4f24\u5f27\u83cc\u552f\u4e00\u7684\u6377\u5f84\uff01<\/p>\n \u5357\u65b9\u90fd\u5e02\u62a5\u7efc\u5408\u4e0a\u6d77\u5e02\u7b2c\u516d\u4eba\u6c11\u533b\u9662<\/p>\n","protected":false},"excerpt":{"rendered":" \u4e00\u6b21\u770b\u4f3c\u5bfb\u5e38\u7684\u201c\u9c7c\u523a\u624e\u624b\u201d\uff0c\u5374\u53ef\u80fd\u9690\u85cf\u7740\u8db3\u4ee5\u81f4\u547d\u7684\u5371\u673a\uff01 \u8fd1\u65e5(4\u670830\u65e5)\uff0c\u4e0a\u6d77\u5e02\u7b2c\u516d\u4eba\u6c11\u533b\u9662\u516c\u5e03\u4e86\u4e00\u5219\u75c5\u4f8b\uff1a \u65e9\u524d\uff0c\u8be5\u9662\u611f\u67d3\u75c5\u79d1\u6536\u6cbb\u4e86\u4e00\u4f8b\u56e0\u9c7c\u523a\u523a\u4f24\u5bfc\u81f4\u521b\u4f24\u5f27\u83cc\u611f\u67d3\u7684\u5371\u91cd\u75c5\u4f8b\u3002\u60a3\u8005\u5728\u5904\u7406\u6d77\u4ea7\u54c1\u65f6\u4e0d\u614e\u88ab\u9c7c\u523a\u624e\u4f24\u5de6\u624b\u4e2d\u6307\uff0c\u75c5\u60c5\u572824\u5c0f\u65f6\u5185\u6025\u5267\u6076\u5316\uff0c\u7ecf\u591a\u5b66\u79d1\u534f\u4f5c\u6551\u6cbb\u540e\u8f6c\u5371\u4e3a\u5b89\u3002 \u4e00\u6b21\u758f\u5ffd\uff1a \u6307\u5c16\u4e0a\u7684\u201c\u9690\u5f62\u6740\u624b\u201d 3\u670816\u65e5\uff0c70\u591a\u5c81\u7684\u674e\u963f\u59e8(\u5316\u540d)\u5728\u5904\u7406\u6d77\u4ea7\u54c1\u65f6\u4e0d\u614e\u88ab\u9c7c\u523a\u624e\u4f24\u4e86\u5de6\u624b\u4e2d\u6307\u3002\u8d77\u521d\uff0c\u5979\u53ea\u662f\u7b80\u5355\u51b2\u6d17\u6d88\u6bd2\uff0c\u5e76\u672a\u91cd\u89c6\u3002 \u53ef\u4ec5\u4ec5\u8fc7\u4e86\u4e00\u5929\uff0c\u60c5\u51b5\u5c31\u6025\u8f6c\u76f4\u4e0b\uff1a\u5de6\u624b\u50cf\u5145\u4e86\u6c14\u4e00\u6837\u8fc5\u901f\u80bf\u80c0\uff0c\u75bc\u75db\u94bb\u5fc3\uff0c\u7ea2\u80bf\u987a\u7740\u624b\u6307\u4e00\u8def\u8513\u5ef6\u5230\u4e86\u624b\u8155\u3002\u6b21\u65e5\u674e\u963f\u59e8\u51fa\u73b0\u9ad8\u70ed\uff0c\u4f53\u6e29\u6700\u9ad8\u81f339.7\u2103\u3002 \u5bb6\u5c5e\u7d27\u6025\u9001\u533b\u540e\uff0c\u8840\u5e38\u89c4\u663e\u793a\u767d\u7ec6\u80de\u5347\u523016.03\u00d710\u2079\/L\uff0c\u708e\u75c7\u6307\u6807\u660e\u663e\u5347\u9ad8\uff0c\u7d27\u6025\u6536\u6cbb\u81f3\u611f\u67d3\u75c5\u79d1\u3002 \u53cc\u91cd\u8003\u9a8c\uff1a \u57fa\u7840\u75c5\u7f20\u8eab\u7684\u201c\u9ad8\u5371\u65f6\u523b\u201d \u5165\u9662\u540e\uff0c\u611f\u67d3\u75c5\u79d1\u56e2\u961f\u8be6\u7ec6\u8be2\u95ee\u75c5\u53f2\uff0c\u4e86\u89e3\u5230\u674e\u963f\u59e8\u66fe\u7ecf\u63a5\u89e6\u8fc7\u6d77\u9c7c\uff0c\u5e76\u4e14\u4f24\u53e3\u80bf\u80c0\u8fdb\u5c55\u5341\u5206\u8fc5\u901f\uff0c\u9ad8\u5ea6\u6000\u7591\u4e3a\u521b\u4f24\u5f27\u83cc\u3002\u8fd9\u7c7b\u75c5\u539f\u83cc\u6781\u4e3a\u51f6\u9669\uff0c\u75c5\u60c5\u8fdb\u5c55\u8fc5\u901f\uff0c\u4e25\u91cd\u8005\u9700\u622a\u80a2\u3002\u63a5\u8bca\u533b\u751f\u7acb\u5373\u542f\u52a8\u5e94\u6025\u9884\u6848\uff0c\u7ecf\u9a8c\u6027\u7ed9\u4e88\u5934\u5b62\u54cc\u916e\u8212\u666e\u6df1\u8054\u5408\u5de6\u6c27\u6c1f\u6c99\u661f\u6297\u611f\u67d3\u6cbb\u7597\uff0c\u5373\u523b\u8bf7\u9aa8\u79d1\u4f1a\u8bca\u8bc4\u4f30\u624b\u672f\u6307\u5f81\u3002 \u674e\u963f\u59e8\u7684\u75c5\u60c5\u4e4b\u6240\u4ee5\u68d8\u624b\uff0c\u4e0d\u4ec5\u662f\u56e0\u4e3a\u611f\u67d3\u51f6\u731b\uff0c\u66f4\u56e0\u4e3a\u5979\u662f\u4e00\u4f4d\u5fc3\u810f\u74e3\u819c\u7f6e\u6362\u53ca\u8d77\u640f\u5668\u690d\u5165\u672f\u540e\u7684\u60a3\u8005\uff0c\u957f\u671f\u670d\u7528\u6297\u51dd\u836f\uff1b\u540c\u65f6\u5408\u5e76\u7cd6\u5c3f\u75c5\uff0c\u5165\u9662\u65f6\u5df2\u51fa\u73b0\u7cd6\u5c3f\u75c5\u916e\u75c7\u3002 \u201c\u91cd\u75c7\u611f\u67d3+\u5fc3\u810f\u75c5+\u7cd6\u5c3f\u75c5\u916e\u75c7\u201d\u4e09\u8005\u53e0\u52a0\uff0c\u75c5\u60c5\u5371\u91cd\uff0c\u6781\u6613\u5f15\u53d1\u8113\u6bd2\u6027\u4f11\u514b\u6216\u5fc3\u8870\u3002 \u60a3\u8005\u624b\u90e8\u80bf\u80c0\u660e\u663e\uff0c\u5ef6\u53ca\u624b\u8155\uff0c\u624b\u6307\u5c40\u90e8\u51fa\u73b0\u6c34\u75b1\u3002 \u751f\u6b7b\u62a2\u6551\uff1a \u591a\u5b66\u79d1\u56e2\u961f\u201c\u62a2\u56de\u624b\u6307\u201d \u9aa8\u79d1\u4e0e\u611f\u67d3\u75c5\u79d1\u5171\u540c\u8bc4\u4f30\u540e\uff0c\u51b3\u5b9a\u5c3d\u5feb\u624b\u672f\u5207\u5f00\u51cf\u538b\u3001\u5f15\u6d41\u30023\u670819\u65e5\uff0c\u674e\u963f\u59e8\u63a5\u53d7\u4e86\u5de6\u624b\u6e05\u521b\u53ca\u5207\u5f00\u5f15\u6d41\u672f\u3002\u9488\u5bf9\u521b\u4f24\u5f27\u83cc\u611f\u67d3\u6613\u51fa\u73b0\u7ec4\u7ec7\u574f\u6b7b\u8fdb\u5c55\u7684\u7279\u70b9\uff0c\u672f\u540e\u56e2\u961f\u5bc6\u5207\u76d1\u6d4b\u4f24\u53e3\u60c5\u51b5\u3002\u7531\u4e8e\u611f\u67d3\u8303\u56f4\u8f83\u5e7f\uff0c\u6309\u8bca\u7597\u89c4\u8303\u4e8e3\u670826\u65e5\u518d\u6b21\u884c\u6e05\u521b\u672f\uff0c\u6e05\u695a\u6b8b\u4f59\u574f\u6b7b\u7ec4\u7ec7\uff0c\u5e76\u653e\u7f6eVSD\u8d1f\u538b\u5f15\u6d41\u88c5\u7f6e\u3002\u533b\u751f\u5c06\u672f\u4e2d\u7684\u7ec4\u7ec7\u6db2\u9001\u68c0\u5b8f\u57fa\u56e0\u68c0\u6d4b(NGS\u68c0\u6d4b)\u3002\u6b21\u65e5\u7ed3\u679c\u56de\u62a5\uff0c\u652f\u6301\u6700\u521d\u7684\u5224\u65ad\u2014\u2014\u521b\u4f24\u5f27\u83cc(Vibrio vulnificus)\uff0c\u5e8f\u5217\u6570\u9ad8\u8fbe\u5341\u51e0\u4e07\u6761\u3002\u6839\u636e\u75c5\u539f\u5b66\uff0c\u56e2\u961f\u4f7f\u7528\u5934\u5b62\u54cc\u916e\u94a0\u8212\u5df4\u5766\u94a0+\u5de6\u6c27\u6c1f\u6c99\u661f\u8054\u5408\u6297\u611f\u67d3\u3002 \u9274\u4e8e\u674e\u963f\u59e8\u6709\u673a\u68b0\u74e3\u819c\u7f6e\u6362\u53f2\uff0c\u957f\u671f\u5403\u534e\u6cd5\u6797\u6297\u51dd\uff0c\u672f\u524d\u505c\u7528\uff0c\u4f4f\u9662\u671f\u95f4\u5bc6\u5207\u76d1\u6d4bINR\u6307\u6807\uff0c\u52a8\u6001\u8c03\u6574\u6297\u51dd\u65b9\u6848\u3002\u540c\u65f6\uff0c\u8bf7\u5185\u5206\u6ccc\u4ee3\u8c22\u79d1\u534f\u540c\u8bca\u6cbb\uff0c\u4e88\u80f0\u5c9b\u7d20\u6cf5\u63a7\u5236\u9ad8\u8840\u7cd6\uff0c\u5e76\u8fdb\u884c\u6d88\u916e\u6cbb\u7597\u3002 \u672f\u4e2d\u8113\u6db2\u9001\u68c0mNGS\u68c0\u6d4b\u3002 \u7ecf\u8fc72\u5468\u594b\u6218\uff0c\u674e\u963f\u59e8\u7684\u4f53\u6e29\u6062\u590d\u6b63\u5e38\uff0c\u5de6\u624b\u80bf\u80c0\u6d88\u9000\uff0c\u708e\u75c7\u6307\u6807\u9010\u6b65\u4e0b\u964d\uff0c\u8840\u7cd6\u7a33\u5b9a\uff0c\u6700\u7ec8\u8131\u79bb\u5371\u9669\u5e76\u51fa\u9662\u3002 \u672f\u540e\u5207\u53e3\u5e72\u71e5\uff0c\u6108\u5408\u826f\u597d\uff0c\u624b\u80cc\u80bf\u80c0\u660e\u663e\u6d88\u9000\u3002 \u79d1\u666e\u5c0f\u77e5\u8bc6 \u521b\u4f24\u5f27\u83cc\u88ab\u79f0\u4e3a\u201c\u6d77\u6d0b\u4e2d\u7684\u65e0\u60c5\u6740\u624b\u201d\u6216\u201c\u98df\u8089\u83cc\u201d\uff0c\u5e38\u5bc4\u751f\u5728\u7261\u86ce\u3001\u868c\u7c7b\u7b49\u6d77\u9c9c\u4e2d\u3002\u4e00\u65e6\u901a\u8fc7\u4f24\u53e3\u8fdb\u5165\u4eba\u4f53\uff0c\u8d77\u75c5\u6025\u3001\u8fdb\u5c55\u5feb\uff0c\u5982\u679c\u4e0d\u53ca\u65f6\u5904\u7406\uff0c48\u5c0f\u65f6\u5185\u6b7b\u4ea1\u7387\u8d85\u8fc750%\uff0c\u8d85\u8fc772\u5c0f\u65f6\u672a\u6cbb\u7597\u6b7b\u4ea1\u7387\u63a5\u8fd1100%\u3002\u56e0\u6b64\uff0c\u63d0\u9ad8\u9632\u8303\u610f\u8bc6\u3001\u53ca\u65f6\u5c31\u533b\u81f3\u5173\u91cd\u8981\u3002 1.\u57fa\u672c\u7279\u6027 \u5c5e\u4e8e\u5f27\u83cc\u79d1\uff0c\u9769\u5170\u6c0f\u9634\u6027\u83cc\uff0c\u5448\u68d2\u72b6\u6216\u5f27\u72b6\uff0c\u6709\u5355\u6781\u7aef\u97ad\u6bdb\uff0c\u80fd\u5728\u6c34\u4e2d\u72ec\u7acb\u751f\u5b58\u3002\u55dc\u76d0\u3001\u55dc\u6e29\uff0c\u9002\u5b9c\u7e41\u6b96\u6e29\u5ea6\u4e3a20\u2103-30\u2103\uff0c\u76d0\u5ea60\u2030-18\u2030\uff0c\u6c34\u6e29\u4f4e\u4e8e13\u2103\u65f6\u8fdb\u5165\u4f11\u7720\u671f\u3002\u5e38\u5bc4\u751f\u4e8e\u8d1d\u7c7b\u3001\u9c7c\u3001\u867e\u3001\u87f9\u7b49\u6d77\u6d0b\u751f\u7269\u8868\u9762\uff0c\u5c24\u5176\u559c\u6b22\u9c7c\u7c7b\u7684\u9ccd\u3001\u5c3e\u7b49\u5c16\u9510\u90e8\u4f4d\u3002 2.\u611f\u67d3\u9014\u5f84 \u4f24\u53e3\u611f\u67d3\uff1a\u76ae\u80a4\u6709\u7834\u635f(\u5982\u5212\u4f24\u3001\u523a\u4f24)\u65f6\uff0c\u63a5\u89e6\u542b\u521b\u4f24\u5f27\u83cc\u7684\u6d77\u6c34\u6216\u6d77\u4ea7\u54c1\uff0c\u7ec6\u83cc\u901a\u8fc7\u4f24\u53e3\u4fb5\u5165\u4eba\u4f53\u3002 \u7ecf\u53e3\u611f\u67d3\uff1a\u98df\u7528\u672a\u716e\u719f\u6216\u751f\u7684\u53d7\u6c61\u67d3\u6d77\u9c9c\uff0c\u5c24\u5176\u662f\u8d1d\u7c7b(\u5982\u7261\u86ce\u3001\u86e4\u870a)\uff0c\u7ec6\u83cc\u7ecf\u6d88\u5316\u9053\u8fdb\u5165\u4f53\u5185\u3002 3.\u75c7\u72b6\u8868\u73b0 \u4f24\u53e3\u611f\u67d3\u578b\uff1a\u521d\u671f\u4f24\u53e3\u5468\u56f4\u7ea2\u80bf\u3001\u75bc\u75db\uff0c\u8fc5\u901f\u53d1\u5c55\u4e3a\u6c34\u75b1\u3001\u8840\u75b1\uff0c\u76ae\u80a4\u5448\u9ed1\u7d2b\u8272\uff0c\u53ef\u8513\u5ef6\u81f3\u80a2\u4f53\u5176\u4ed6\u90e8\u4f4d\uff0c\u4e25\u91cd\u65f6\u51fa\u73b0\u808c\u8089\u574f\u6b7b\u3001\u574f\u75bd\u3002 \u8113\u6bd2\u75c7\u578b\uff1a\u611f\u67d3\u540e24-48\u5c0f\u65f6\u5185\u51fa\u73b0\u9ad8\u70ed\u3001\u5bd2\u6218\u3001\u4f4e\u8840\u538b\u3001\u795e\u5fd7\u6a21\u7cca\u7b49\u75c7\u72b6\uff0c\u53ef\u80fd\u8fc5\u901f\u8fdb\u5c55\u4e3a\u591a\u5668\u5b98\u529f\u80fd\u8870\u7aed\u3002 \u80c3\u80a0\u708e\u578b\uff1a\u98df\u7528\u6c61\u67d3\u6d77\u9c9c\u540e\u51fa\u73b0\u8179\u75db\u3001\u8179\u6cfb\u3001\u5455\u5410\u3001\u53d1\u70ed\u7b49\u6d88\u5316\u9053\u75c7\u72b6\uff0c\u4e00\u822c\u8f83\u8f7b\uff0c\u4f46\u514d\u75ab\u529b\u4f4e\u4e0b\u8005\u53ef\u80fd\u8f6c\u4e3a\u91cd\u75c7\u3002 4.\u9ad8\u5371\u4eba\u7fa4 \u6162\u6027\u809d\u75c5\u60a3\u8005(\u5982\u809d\u786c\u5316\u3001\u9152\u7cbe\u6027\u809d\u75c5)\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u3001\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u8005(\u5982\u957f\u671f\u4f7f\u7528\u514d\u75ab\u6291\u5236\u5242\u3001\u827e\u6ecb\u75c5\u60a3\u8005)\u3001\u957f\u671f\u55dc\u9152\u8005\u3001\u8001\u5e74\u4eba\u7b49\uff0c\u611f\u67d3\u540e\u75c5\u60c5\u66f4\u6613\u6076\u5316\uff0c\u6b7b\u4ea1\u7387\u8f83\u9ad8\u3002 5.\u6e29\u99a8\u63d0\u793a \u5904\u7406\u6d77\u9c9c\u65f6\u8bf7\u52a1\u5fc5\u4f69\u6234\u6a61\u80f6\u539a\u624b\u5957\uff0c\u907f\u514d\u76ae\u80a4\u88ab\u523a\u4f24\uff1b \u6d77\u9c9c\u5f7b\u5e95\u716e\u719f\u540e\u98df\u7528\uff0c\u907f\u514d\u751f\u98df\u6216\u534a\u751f\u98df\uff1b \u6709\u4f24\u53e3\u65f6\u907f\u514d\u63a5\u89e6\u6d77\u6c34\u6216\u6d77\u4ea7\u54c1\uff1b \u82e5\u88ab\u523a\u4f24\u6216\u98df\u7528\u6d77\u9c9c\u540e\u51fa\u73b0\u7ea2\u80bf\u3001\u53d1\u70ed\u3001\u8179\u75db\u7b49\u75c7\u72b6\uff0c\u7acb\u5373\u7528\u6e05\u6c34\u51b2\u6d17\u4f24\u53e3\uff0c\u7528\u7898\u4f0f\u6216\u9152\u7cbe\u6d88\u6bd2\uff0c\u8bf7\u7b2c\u4e00\u65f6\u95f4\u524d\u5f80\u533b\u9662\uff0c\u5e76\u4e3b\u52a8\u544a\u77e5\u533b\u751f\u6d77\u6c34\u6216\u6d77\u9c9c\u63a5\u89e6\u53f2\uff1b \u60a3\u6709\u7cd6\u5c3f\u75c5\u3001\u6162\u6027\u809d\u75c5\u6216\u514d\u75ab\u529b\u4f4e\u4e0b\u7684\u4eba\u7fa4\uff0c\u66f4\u5bb9\u6613\u611f\u67d3\u521b\u4f24\u5f27\u83cc\uff0c\u66f4\u5e94\u52a0\u5f3a\u9632\u62a4\u3002 \u5982\u679c\u60a8\u6216\u60a8\u7684\u5bb6\u4eba\u5728\u5904\u7406\u6d77\u9c9c\u540e\u611f\u5230\u4e0d\u9002\uff0c\u8bf7\u7b2c\u4e00\u65f6\u95f4\u524d\u5f80\u6b63\u89c4\u533b\u9662\u5c31\u8bca\u3002\u65e9\u53d1\u73b0\u3001\u65e9\u8bca\u65ad\u3001\u65e9\u6cbb\u7597\uff0c\u662f\u5bf9\u6297\u521b\u4f24\u5f27\u83cc\u552f\u4e00\u7684\u6377\u5f84\uff01 \u5357\u65b9\u90fd\u5e02\u62a5\u7efc\u5408\u4e0a\u6d77\u5e02\u7b2c\u516d\u4eba\u6c11\u533b\u9662<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2056],"tags":[12909],"class_list":["post-413700","post","type-post","status-publish","format-standard","hentry","category-2056","tag-12909"],"_links":{"self":[{"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/posts\/413700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/comments?post=413700"}],"version-history":[{"count":0,"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/posts\/413700\/revisions"}],"wp:attachment":[{"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/media?parent=413700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/categories?post=413700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/6gnx6dd.cc\/index.php\/wp-json\/wp\/v2\/tags?post=413700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}