\u5f88\u591a\u4eba\u90fd\u6709\u8fd9\u6837\u7684\u7ecf\u5386\uff1a\u8fd9\u4e2a\u6708\u8ff7\u4e0a\u4e86\u6e38\u6cf3\uff0c\u4e0b\u4e2a\u6708\u6539\u8dd1\u6b65\uff0c\u518d\u8fc7\u4e00\u9635\u5b50\u53c8\u8ff7\u4e0a\u4e86\u5065\u8eab\u623f\u2014\u2014\u7136\u540e\u5f00\u59cb\u6000\u7591\u81ea\u5df1\u662f\u4e0d\u662f\u592a\u6ca1\u6709\u6bc5\u529b\u4e86\u3002<\/p>\n
\u4f46\u6700\u65b0\u7684\u8fd0\u52a8\u79d1\u5b66\u7814\u7a76\u7ed9\u51fa\u4e86\u4e00\u4e2a\u610f\u60f3\u4e0d\u5230\u7684\u7b54\u6848\uff1a\u8fd9\u79cd\u201c\u82b1\u6837\u767e\u51fa\u201d\u7684\u8fd0\u52a8\u65b9\u5f0f\uff0c\u53ef\u80fd\u624d\u662f\u6700\u806a\u660e\u7684\u9009\u62e9\u3002<\/strong><\/p>\n \u505a\u8fd0\u52a8\u7684\u201c\u5168\u80fd\u201d\u73a9\u5bb6<\/strong><\/p>\n \u54c8\u4f5b\u5927\u5b66\u4e00\u9879\u6db5\u76d6\u8d85\u8fc7 11 \u4e07\u4eba\u7684\u5927\u578b\u7814\u7a76\u8ffd\u8e2a\u4e86\u6765\u81ea\u201c\u62a4\u58eb\u5065\u5eb7\u7814\u7a76\u201d(Nurses’ Health Study)\u548c\u201c\u536b\u751f\u4e13\u4e1a\u4eba\u5458\u968f\u8bbf\u7814\u7a76\u201d(Health Professionals Follow-Up Study)\u7684 111,467 \u540d\u53c2\u4e0e\u8005\u3002\u7ed3\u679c\u53d1\u73b0\u4e86\u4e00\u4e2a\u4ee4\u4eba\u610f\u5916\u7684\u89c4\u5f8b\uff1a\u8fd0\u52a8\u79cd\u7c7b\u7684\u591a\u6837\u6027\uff0c\u4e0e\u66f4\u4f4e\u7684\u6b7b\u4ea1\u7387\u4e4b\u95f4\u5b58\u5728\u72ec\u7acb\u7684\u76f8\u5173\u6027\u3002<\/strong><\/p>\n \u201c\u72ec\u7acb\u201d\u8fd9\u4e24\u4e2a\u5b57\u5f88\u5173\u952e\uff0c\u56e0\u4e3a\u5b83\u8bf4\u660e\u54ea\u6015\u4e24\u4e2a\u4eba\u7684\u8fd0\u52a8\u603b\u91cf\u5b8c\u5168\u76f8\u540c\uff0c\u53c2\u4e0e\u8fd0\u52a8\u79cd\u7c7b\u66f4\u591a\u7684\u90a3\u4e2a\u4eba\u6b7b\u4ea1\u98ce\u9669\u4f9d\u7136\u66f4\u4f4e<\/strong>\u2014\u2014\u4f4e\u4e86\u6574\u6574 19%\u3002<\/p>\n \u4e0d\u4ec5\u5982\u6b64\uff0c\u8fd0\u52a8\u6700\u201c\u82b1\u201d\u7684\u4eba\u7fa4\uff0c\u6b7b\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u764c\u75c7\u3001\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u98ce\u9669\uff0c\u4e5f\u6bd4\u8fd0\u52a8\u6700\u5355\u4e00\u7684\u4eba\u7fa4\u4f4e\u4e86 13% \u5230 41%\u3002<\/p>\n \u80cc\u540e\u7684\u539f\u7406\u5176\u5b9e\u4e0d\u96be\u7406\u89e3\uff1a\u4e0d\u540c\u7c7b\u578b\u7684\u8fd0\u52a8\uff0c\u4f5c\u7528\u7684\u8eab\u4f53\u7cfb\u7edf\u5b8c\u5168\u4e0d\u540c\u3002<\/strong>\u6709\u6c27\u8fd0\u52a8(\u5982\u8dd1\u6b65\u3001\u6e38\u6cf3)\u80fd\u589e\u5f3a\u5fc3\u80ba\u529f\u80fd\uff0c\u4f46\u5bf9\u808c\u8089\u529b\u91cf\u7684\u5f71\u54cd\u76f8\u5bf9\u6709\u9650\uff1b\u53cd\u8fc7\u6765\uff0c\u529b\u91cf\u8bad\u7ec3\u80fd\u8ba9\u808c\u8089\u548c\u9aa8\u9abc\u66f4\u5f3a\u58ee\uff0c\u5374\u51e0\u4e4e\u4e0d\u6539\u53d8\u5fc3\u80ba\u8017\u6c27\u80fd\u529b\u3002\u53ea\u6709\u5c06\u4e0d\u540c\u7684\u8fd0\u52a8\u6a21\u5f0f\u7ed3\u5408\uff0c\u624d\u80fd\u5728\u591a\u4e2a\u5065\u5eb7\u9886\u57df\u540c\u65f6\u83b7\u5f97\u63d0\u5347\u3002<\/p>\n \u7814\u7a76\u8005\u63a8\u8bba\uff0c\u4e0e\u53ea\u4e13\u6ce8\u4e8e\u5355\u4e00\u7c7b\u578b\u7684\u8fd0\u52a8\u76f8\u6bd4\uff0c\u53c2\u4e0e\u5177\u6709\u4e92\u8865\u5065\u5eb7\u6548\u5e94\u7684\u591a\u79cd\u8fd0\u52a8\u80fd\u8ba9\u4e2a\u4f53\u83b7\u76ca\u66f4\u591a\u3002<\/strong>\u603b\u4f53\u800c\u8a00\uff0c\u957f\u671f\u575a\u6301\u591a\u79cd\u7c7b\u578b\u7684\u4f53\u80b2\u953b\u70bc\u6709\u52a9\u4e8e\u5ef6\u957f\u5bff\u547d\u3002<\/p>\n \u82b1\u6837\u8fd0\u52a8\uff0c\u8ba9\u5927\u8111\u201c\u8d8a\u7ec3\u8d8a\u5e74\u8f7b\u201d<\/strong><\/p>\n \u9664\u4e86\u5bf9\u8eab\u4f53\u7684\u597d\u5904\uff0c\u201c\u82b1\u6837\u8fd0\u52a8\u201d\u5bf9\u5927\u8111\u4e5f\u540c\u6837\u76ca\u5904\u9887\u591a\u3002<\/p>\n \u591a\u9879\u7814\u7a76\u8868\u660e\uff0c\u575a\u6301\u953b\u70bc\u7684\u4eba\uff0c\u5927\u8111\u4e2d\u8d1f\u8d23\u601d\u8003\u548c\u8bb0\u5fc6\u7684\u533a\u57df\u4f53\u79ef\u5f80\u5f80\u66f4\u5927\u3002<\/strong>\u800c\u4e14\uff0c\u53ea\u9700\u575a\u6301 6 \u5230 12 \u4e2a\u6708\u7684\u4e2d\u7b49\u5f3a\u5ea6\u89c4\u5f8b\u8fd0\u52a8\uff0c\u5c31\u80fd\u8ba9\u5927\u8111\u7279\u5b9a\u533a\u57df\u7684\u4f53\u79ef\u663e\u8457\u589e\u52a0\u2014\u2014\u5c24\u5176\u662f\u4e0e\u8bb0\u5fc6\u5bc6\u5207\u76f8\u5173\u7684\u201c\u6d77\u9a6c\u4f53\u201d\uff0c\u8fd0\u52a8\u80fd\u6709\u6548\u4fdd\u62a4\u5b83\u514d\u4e8e\u840e\u7f29\u548c\u8ba4\u77e5\u8870\u9000\u3002<\/p>\n \u4e0d\u540c\u7c7b\u578b\u7684\u8fd0\u52a8\uff0c\u5bf9\u5927\u8111\u7684\u5f71\u54cd\u5404\u4e0d\u76f8\u540c\uff1a<\/strong><\/p>\n \u00b7 \u6709\u6c27\u8fd0\u52a8(\u5982\u8dd1\u6b65\u3001\u6e38\u6cf3\u3001\u5feb\u8d70\u7b49)\uff1a<\/strong>\u9ad8\u5f3a\u5ea6\u7684\u6709\u6c27\u6216\u8010\u529b\u8fd0\u52a8\u80fd\u663e\u8457\u63d0\u5347\u8840\u6db2\u4e2d\u7684\u5927\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50(BDNF)\u6c34\u5e73\uff0c\u4ece\u800c\u4fc3\u8fdb\u6d77\u9a6c\u4f53\u795e\u7ecf\u53d1\u751f\u548c\u7a81\u89e6\u53ef\u5851\u6027\u3002\u6b64\u5916\uff0c\u6709\u6c27\u8fd0\u52a8\u8fd8\u4f1a\u8bf1\u5bfc\u9aa8\u9abc\u808c\u91ca\u653e\u7ec4\u7ec7\u86cb\u767d\u9176 B(Cathepsin B)\u548c\u9e22\u5c3e\u7d20(Irisin)\u7b49\u7269\u8d28\uff0c\u8fd9\u4e9b\u5206\u5b50\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u540e\uff0c\u80fd\u6539\u5584\u7a7a\u95f4\u8bb0\u5fc6\u548c\u6267\u884c\u529f\u80fd\u3002<\/p>\n \u00b7\u963b\u529b\u4e0e\u529b\u91cf\u8bad\u7ec3\uff1a<\/strong>\u6e10\u8fdb\u5f0f\u7684\u963b\u529b\u8bad\u7ec3\u80fd\u591f\u589e\u5f3a\u5927\u8111\u7684\u5de5\u4f5c\u8bb0\u5fc6\u548c\u4efb\u52a1\u5207\u6362\u80fd\u529b\uff0c\u5e76\u4e0e\u5927\u8111\u540e\u6263\u5e26\u76ae\u5c42(Posterior cingulate cortex)(\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e2d\u7684\u6613\u635f\u533a\u57df)\u7684\u529f\u80fd\u8fde\u63a5\u6027\u6539\u53d8\u6709\u5173\u3002<\/p>\n \u00b7\u8eab\u5fc3\u8fd0\u52a8(\u5982\u592a\u6781\u62f3)\uff1a<\/strong>\u592a\u6781\u62f3\u7b49\u8fd0\u52a8\u4e0d\u4ec5\u6d89\u53ca\u8eab\u4f53\u6d3b\u52a8\uff0c\u8fd8\u5305\u542b\u7f13\u6162\u3001\u4e13\u6ce8\u7684\u52a8\u4f5c\uff0c\u9700\u8981\u5927\u8111\u4e0d\u65ad\u5b66\u4e60\u548c\u8bb0\u5fc6\u65b0\u7684\u6280\u80fd\u4e0e\u8fd0\u52a8\u6a21\u5f0f\u3002\u8fd9\u79cd\u8111\u4f53\u7ed3\u5408\u7684\u7279\u6027\uff0c\u4f7f\u5176\u80fd\u591f\u63d0\u5347\u8001\u5e74\u4eba\u5927\u8111\u7684\u5904\u7406\u901f\u5ea6\u3001\u6ce8\u610f\u529b\u5bb9\u91cf\uff0c\u4ee5\u53ca\u6db5\u76d6\u8ba1\u5212\u3001\u5de5\u4f5c\u8bb0\u5fc6\u548c\u8bed\u8a00\u63a8\u7406\u5728\u5185\u7684\u6267\u884c\u529f\u80fd\u3002<\/p>\n 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23%\u3002\u804c\u4e1a\u68d2\u7403\u9886\u57df\u7684\u7814\u7a76\u4e5f\u5370\u8bc1\u4e86\u8fd9\u4e00\u70b9\u2014\u2014\u6709\u591a\u9879\u8fd0\u52a8\u80cc\u666f\u7684\u7403\u5458\uff0c\u4e0a\u80a2\u8fc7\u5ea6\u4f7f\u7528\u635f\u4f24\u7684\u53d1\u751f\u7387\u660e\u663e\u66f4\u4f4e(13%)\u3002<\/p>\n \u539f\u56e0\u5728\u4e8e\uff0c\u5927\u591a\u6570\u8fd0\u52a8\u635f\u4f24\u6765\u81ea\u201c\u8fc7\u5ea6\u4f7f\u7528\u201d\u3002\u540c\u4e00\u5757\u808c\u8089\u3001\u540c\u4e00\u6839\u808c\u8171\u3001\u540c\u4e00\u5757\u9aa8\u9abc\u88ab\u53cd\u590d\u65bd\u538b\uff0c\u5fae\u5c0f\u521b\u4f24\u4e0d\u65ad\u7d2f\u79ef\uff0c\u6700\u7ec8\u917f\u6210\u4f24\u75c5\u3002\u800c\u82b1\u6837\u8fd0\u52a8\u80fd\u591f\u628a\u538b\u529b\u5206\u6563\u5230\u8eab\u4f53\u7684\u4e0d\u540c\u90e8\u4f4d\uff0c\u8ba9\u6bcf\u4e2a\u533a\u57df\u90fd\u6709\u5145\u5206\u7684\u6062\u590d\u65f6\u95f4\u3002<\/strong><\/p>\n \u6b64\u5916\uff0c\u65e9\u671f\u63a5\u89e6\u591a\u79cd\u8fd0\u52a8\uff0c\u8fd8\u80fd\u5e2e\u52a9\u8eab\u4f53\u5efa\u7acb\u66f4\u5e7f\u6cdb\u7684\u8fd0\u52a8\u6280\u80fd\u57fa\u7840\u2014\u2014\u66f4\u597d\u7684\u843d\u5730\u53d1\u529b\u673a\u5236\u3001\u66f4\u5f3a\u7684\u795e\u7ecf\u808c\u8089\u63a7\u5236\u3001\u66f4\u7075\u6d3b\u7684\u53d8\u5411\u80fd\u529b\u3002\u8fd9\u4e9b\u57fa\u7840\u80fd\u529b\uff0c\u6b63\u662f\u9884\u9632\u524d\u4ea4\u53c9\u97e7\u5e26\u635f\u4f24\u7b49\u5e38\u89c1\u4f24\u75c5\u7684\u6838\u5fc3\u8981\u7d20\u3002<\/p>\n \u201c\u4e09\u5206\u949f\u70ed\u5ea6\u201d\u521a\u521a\u597d\uff0c<\/strong><\/p>\n \u65b0\u9c9c\u611f\u662f\u575a\u6301\u7684\u52a8\u529b\u6e90<\/strong><\/p>\n \u5f88\u591a\u4eba\u6216\u8bb8\u4f1a\u62c5\u5fc3\uff0c\u8fd0\u52a8\u79cd\u7c7b\u6362\u6765\u6362\u53bb\uff0c\u4f1a\u4e0d\u4f1a\u53cd\u800c\u575a\u6301\u4e0d\u4e0b\u53bb\uff1f<\/p>\n \u4f46\u6570\u636e\u7ed9\u51fa\u4e86\u622a\u7136\u76f8\u53cd\u7684\u7b54\u6848\u3002\u4e00\u9879\u9488\u5bf9\u7f3a\u4e4f\u8fd0\u52a8\u7684\u5927\u5b66\u751f\u7684\u5b9e\u9a8c\u53d1\u73b0\uff0c\u88ab\u5b89\u6392\u201c\u6bcf\u6b21\u505a\u4e0d\u540c\u6297\u963b\u52a8\u4f5c\u7ec4\u5408\u201d\u7684\u5b66\u751f\uff0c\u5bf9\u8fd0\u52a8\u8ba1\u5212\u7684\u4f9d\u4ece\u7387\u8fbe\u5230\u4e86 64%\uff1b\u800c\u6bcf\u6b21\u91cd\u590d\u5b8c\u5168\u76f8\u540c\u52a8\u4f5c\u7684\u5b66\u751f\uff0c\u4f9d\u4ece\u7387\u53ea\u6709 51%\u3002<\/p>\n \u6240\u4ee5\u8bf4\uff0c\u65b0\u9c9c\u611f\uff0c\u624d\u662f\u575a\u6301\u8fd0\u52a8\u6700\u5f3a\u7684\u5185\u9a71\u529b\u3002<\/strong><\/p>\n 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\u529b\u91cf\u7a7f\u63d2\uff1a\u52a0\u5165\u6297\u963b\/\u529b\u91cf\u8bad\u7ec3\uff0c\u5f3a\u5316\u808c\u8089\u9aa8\u9abc\uff0c\u63d0\u5347\u5927\u8111\u6267\u884c\u529f\u80fd\u3002<\/p>\n \u00b7 \u8eab\u5fc3\u70b9\u7f00\uff1a\u5076\u5c14\u52a0\u5165\u592a\u6781\u3001\u745c\u4f3d\u7b49\u9700\u8981\u4e13\u6ce8\u548c\u5b66\u4e60\u65b0\u52a8\u4f5c\u7684\u8fd0\u52a8\uff0c\u63d0\u5347\u6ce8\u610f\u529b\u548c\u5e73\u8861\u611f\u3002<\/p>\n 2 \u5fc3\u7406\u4fdd\u9c9c\uff1a\u5728\u4e09\u4e2a\u5c42\u9762\u5236\u9020\u201c\u65b0\u9c9c\u611f\u201d<\/strong><\/p>\n \u00b7 \u5929\u4e0e\u5929\u4e4b\u95f4\uff1a\u4e0d\u8981\u6bcf\u5929\u505a\u540c\u6837\u7684\u8fd0\u52a8\u3002\u4f8b\u5982\uff0c\u5468\u4e00\u8dd1\u6b65\u3001\u5468\u4e09\u6e38\u6cf3\u3001\u5468\u4e94\u529b\u91cf\u8bad\u7ec3\u3002<\/p>\n \u00b7\u5355\u6b21\u8bad\u7ec3\u5185\uff1a\u540c\u4e00\u6b21\u5065\u8eab\uff0c\u6df7\u642d\u5668\u68b0\u3001\u81ea\u7531\u91cd\u91cf\u548c\u81ea\u91cd\u52a8\u4f5c\u3002<\/p>\n 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Professionals Follow-Up Study)\u7684 111,467 \u540d\u53c2\u4e0e\u8005\u3002\u7ed3\u679c\u53d1\u73b0\u4e86\u4e00\u4e2a\u4ee4\u4eba\u610f\u5916\u7684\u89c4\u5f8b\uff1a\u8fd0\u52a8\u79cd\u7c7b\u7684\u591a\u6837\u6027\uff0c\u4e0e\u66f4\u4f4e\u7684\u6b7b\u4ea1\u7387\u4e4b\u95f4\u5b58\u5728\u72ec\u7acb\u7684\u76f8\u5173\u6027\u3002 \u201c\u72ec\u7acb\u201d\u8fd9\u4e24\u4e2a\u5b57\u5f88\u5173\u952e\uff0c\u56e0\u4e3a\u5b83\u8bf4\u660e\u54ea\u6015\u4e24\u4e2a\u4eba\u7684\u8fd0\u52a8\u603b\u91cf\u5b8c\u5168\u76f8\u540c\uff0c\u53c2\u4e0e\u8fd0\u52a8\u79cd\u7c7b\u66f4\u591a\u7684\u90a3\u4e2a\u4eba\u6b7b\u4ea1\u98ce\u9669\u4f9d\u7136\u66f4\u4f4e\u2014\u2014\u4f4e\u4e86\u6574\u6574 19%\u3002 \u4e0d\u4ec5\u5982\u6b64\uff0c\u8fd0\u52a8\u6700\u201c\u82b1\u201d\u7684\u4eba\u7fa4\uff0c\u6b7b\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u764c\u75c7\u3001\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u98ce\u9669\uff0c\u4e5f\u6bd4\u8fd0\u52a8\u6700\u5355\u4e00\u7684\u4eba\u7fa4\u4f4e\u4e86 13% \u5230 41%\u3002 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