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Baltimore Orioles (38-43, fourth in the AL East) vs. Los Angeles Angels (33-48, fifth in the AL West)

Anaheim, California; Wednesday, 4:07 p.m. EDT

PITCHING PROBABLES: Orioles: Trey Gibson (1-2, 5.81 ERA, 1.71 WHIP, 20 strikeouts); Angels: Jose Soriano (8-4, 3.03 ERA, 1.27 WHIP, 98 strikeouts)

LINE: Orioles -150, Angels +123; over/under is 9 runs

BOTTOM LINE: The Los Angeles Angels and Baltimore Orioles meet on Wednesday with the three-game series tied 1-1.

Los Angeles has an 18-21 record in home games and a 33-48 record overall. The Angels have hit 97 total home runs to rank seventh in the AL.

Baltimore is 38-43 overall and 16-24 on the road. The Orioles have a 6-11 record in games decided by one run.

The matchup Wednesday is the third meeting between these teams this season.

TOP PERFORMERS: Zach Neto has 17 home runs, 39 walks and 39 RBI while hitting .229 for the Angels. Donovan Walton is 14 for 30 with three doubles, three home runs and 10 RBI over the past 10 games.

Pete Alonso has 13 doubles and 18 home runs while hitting .247 for the Orioles. Gunnar Henderson is 10 for 39 with a double, a triple and two home runs over the past 10 games.

LAST 10 GAMES: Angels: 4-6, .258 batting average, 4.96 ERA, outscored by four runs

Orioles: 4-6, .233 batting average, 3.65 ERA, even run differential

INJURIES: Angels: Mike Trout: 10-Day IL (hamstring), Adam Frazier: 10-Day IL (elbow), Gustavo Campero: 10-Day IL (hand), Grayson Rodriguez: 15-Day IL (back), Travis d’Arnaud: 60-Day IL (foot), Sebastian Rivero: 10-Day IL (hand), Yoan Moncada: 60-Day IL (knee), Jack Kochanowicz: 60-Day IL (elbow), Robert Stephenson: 60-Day IL (elbow), Ben Joyce: 60-Day IL (shoulder), Yusei Kikuchi: 60-Day IL (shoulder), Anthony Rendon: 60-Day IL (hip)

Orioles: Jackson Holliday: day-to-day (groin), Blaze Alexander: day-to-day (knee), Adley Rutschman: 7-Day IL (concussion), Dean Kremer: 60-Day IL (quadricep), Cade Povich: 15-Day IL (elbow), Ryan Mountcastle: 60-Day IL (foot), Chris Bassitt: 15-Day IL (back), Dylan Beavers: 10-Day IL (oblique), Yaramil Hiraldo: 60-Day IL (shoulder), Zach Eflin: 60-Day IL (elbow), Felix Bautista: 60-Day IL (shoulder), Colin Selby: 60-Day IL (shoulder), Jordan Westburg: 60-Day IL (ucl)

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Kansas City Royals (34-46, fifth in the AL Central) vs. Tampa Bay Rays (43-33, second in the AL East)

St. Petersburg, Florida; Wednesday, 6:40 p.m. EDT

PITCHING PROBABLES: Royals: Noah Cameron (4-4, 4.20 ERA, 1.27 WHIP, 70 strikeouts); Rays: Griffin Jax (2-5, 3.67 ERA, 1.31 WHIP, 46 strikeouts)

LINE: Rays -152, Royals +124; over/under is 7 1/2 runs

BOTTOM LINE: The Kansas City Royals play the Tampa Bay Rays after Nick Loftin had four hits on Tuesday in a 12-5 win over the Rays.

Tampa Bay is 26-12 in home games and 43-33 overall. The Rays have gone 28-7 in games when they scored five or more runs.

Kansas City is 34-46 overall and 15-24 on the road. The Royals have gone 17-39 in games when they have given up a home run.

Wednesday’s game is the third meeting between these teams this season.

TOP PERFORMERS: Junior Caminero has 12 doubles, 16 home runs and 37 RBI while hitting .281 for the Rays. Jonathan Aranda is 12 for 38 with a double and a home run over the last 10 games.

Bobby Witt Jr. has 19 doubles, a triple, 10 home runs and 32 RBI for the Royals. Jac Caglianone is 12 for 40 with a double, six home runs and 11 RBI over the last 10 games.

LAST 10 GAMES: Rays: 3-7, .244 batting average, 4.08 ERA, outscored by 11 runs

Royals: 6-4, .303 batting average, 5.11 ERA, outscored opponents by 16 runs

INJURIES: Rays: Jesse Scholtens: 15-Day IL (wrist), Gavin Lux: 60-Day IL (shoulder), Steven Wilson: 60-Day IL (back), Manuel Rodriguez: 60-Day IL (elbow), Jon Heasley: 60-Day IL (elbow), Jake Fraley: 10-Day IL (groin), Ryan Pepiot: 60-Day IL (hip), Edwin Uceta: 60-Day IL (shoulder)

Royals: Maikel Garcia: 10-Day IL (hand), Bobby Witt Jr.: day-to-day (knee), Carlos Estevez: 60-Day IL (foot), Nick Mears: 15-Day IL (shoulder), Kris Bubic: 15-Day IL (elbow), Cole Ragans: 60-Day IL (elbow), Vinnie Pasquantino: 10-Day IL (hand), Kyle Isbel: 10-Day IL (foot), Jonathan India: 60-Day IL (shoulder), James McArthur: 60-Day IL (elbow), Alec Marsh: 60-Day IL (shoulder)

Athletics (38-41, second in the AL West) vs. San Francisco Giants (32-46, fourth in the NL West)

San Francisco; Wednesday, 9:45 p.m. EDT

PITCHING PROBABLES: Athletics: Gage Jump (3-1, 2.37 ERA, 0.99 WHIP, 26 strikeouts); Giants: Tyler Mahle (0-0)

LINE: Athletics -132, Giants +108; over/under is 8 runs

BOTTOM LINE: The Athletics come into the matchup with the San Francisco Giants after losing three games in a row.

San Francisco has gone 15-20 in home games and 32-46 overall. The Giants have the fourth-best team slugging percentage in the majors at .419.

The Athletics are 38-41 overall and 20-18 on the road. The Athletics have the second-ranked team slugging percentage in the AL at .417.

Wednesday’s game is the fifth time these teams square off this season. The Giants are ahead 3-1 in the season series.

TOP PERFORMERS: Luis Arraez has 16 doubles, six triples and three home runs while hitting .321 for the Giants. Rafael Devers is 10 for 36 with three doubles and three home runs over the last 10 games.

Nick Kurtz has 15 doubles, a triple and 19 home runs while hitting .286 for the Athletics. Zack Gelof is 13 for 36 with two doubles and three home runs over the last 10 games.

LAST 10 GAMES: Giants: 5-5, .258 batting average, 3.93 ERA, even run differential

Athletics: 4-6, .254 batting average, 7.50 ERA, outscored by 17 runs

INJURIES: Giants: Luis Arraez: day-to-day (foot), Jose Butto: 60-Day IL (arm), Heliot Ramos: 10-Day IL (quadricep), Tyler Mahle: 15-Day IL (hamstring), Harrison Bader: 10-Day IL (plantar fasciitis), Keaton Winn: 15-Day IL (elbow), Joel Peguero: 60-Day IL (hamstring), Hayden Birdsong: 60-Day IL (forearm), Jason Foley: 60-Day IL (shoulder), Randy Rodriguez: 60-Day IL (elbow), Rowan Wick: 60-Day IL (elbow)

Athletics: Brent Rooker: 10-Day IL (knee), Zack Gelof: day-to-day (hand), Luis Severino: 60-Day IL (shoulder), Mark Leiter Jr.: 15-Day IL (hip), Brooks Kriske: 60-Day IL (shoulder), Denzel Clarke: 60-Day IL (foot), Gunnar Hoglund: 60-Day IL (knee)

Arizona Diamondbacks (40-39, third in the NL West) vs. St. Louis Cardinals (42-35, second in the NL Central)

St. Louis; Wednesday, 7:45 p.m. EDT

PITCHING PROBABLES: Diamondbacks: Mitch Bratt (0-0); Cardinals: Matthew Liberatore (3-4, 5.23 ERA, 1.56 WHIP, 67 strikeouts)

LINE: Cardinals -120, Diamondbacks -102; over/under is 9 runs

BOTTOM LINE: The St. Louis Cardinals take on the Arizona Diamondbacks on Wednesday.

St. Louis has gone 22-18 in home games and 42-35 overall. The Cardinals have a 32-13 record in games when they record eight or more hits.

Arizona is 40-39 overall and 16-22 in road games. The Diamondbacks have gone 28-14 in games when they record at least eight hits.

The teams play Wednesday for the third time this season.

TOP PERFORMERS: Alec Burleson has 20 doubles, a triple and 13 home runs while hitting .288 for the Cardinals. JJ Wetherholt is 16 for 43 with a double and three home runs over the past 10 games.

Geraldo Perdomo has 10 doubles, three triples, four home runs and 27 RBI for the Diamondbacks. Corbin Carroll is 11 for 39 with two doubles, a triple and two home runs over the past 10 games.

LAST 10 GAMES: Cardinals: 5-5, .279 batting average, 5.28 ERA, outscored by six runs

Diamondbacks: 5-5, .237 batting average, 4.60 ERA, outscored by four runs

INJURIES: Cardinals: Ryan Fernandez: 15-Day IL (back), Masyn Winn: day-to-day (thumb), Ramon Urias: 60-Day IL (elbow)

Diamondbacks: Mike Soroka: 15-Day IL (lower body), Jordan Lawlar: 10-Day IL (hamstring), Ryne Nelson: 15-Day IL (elbow), Corbin Burnes: 60-Day IL (elbow), Cristian Mena: 60-Day IL (shoulder), Carlos Santana: 60-Day IL (groin), James McCann: 10-Day IL (quadricep), A.J. Puk: 60-Day IL (elbow), Blake Walston: 60-Day IL (elbow), Andrew Saalfrank: 60-Day IL (shoulder), Justin Martinez: 60-Day IL (elbow)

Texas Rangers (38-41, third in the AL West) vs. Miami Marlins (41-39, third in the NL East)

Miami; Wednesday, 12:10 p.m. EDT

PITCHING PROBABLES: Rangers: Jacob deGrom (6-4, 3.59 ERA, 1.03 WHIP, 98 strikeouts); Marlins: Eury Perez (0-0)

LINE: Rangers -128, Marlins +105; over/under is 7 1/2 runs

BOTTOM LINE: Both the Miami Marlins and the Texas Rangers are looking for a series win with a victory on Wednesday.

Miami has a 41-39 record overall and a 27-17 record in home games. The Marlins have the 10th-ranked team slugging percentage in the NL at .390.

Texas has a 38-41 record overall and a 19-23 record on the road. The Rangers have hit 81 total home runs to rank 10th in the AL.

The teams meet Wednesday for the third time this season.

TOP PERFORMERS:

Josh Jung has 17 doubles, eight home runs and 31 RBI for the Rangers. Wyatt Langford is 15 for 41 with two doubles, four home runs and 10 RBI over the last 10 games.

LAST 10 GAMES: Marlins: 6-4, .245 batting average, 3.83 ERA, outscored opponents by two runs

Rangers: 4-6, .276 batting average, 5.56 ERA, outscored by 19 runs

INJURIES: Marlins: Josh Ekness: 60-Day IL (calf), Liam Hicks: 10-Day IL (back), Janson Junk: 15-Day IL (shin), Andrew Nardi: 60-Day IL (ribs), Eury Perez: 15-Day IL (gracilis), Robby Snelling: 60-Day IL (elbow), Ronny Henriquez: 60-Day IL (elbow), Adam Mazur: 60-Day IL (elbow)

Rangers: Evan Carter: 10-Day IL (oblique), Robert Garcia: 60-Day IL (shoulder), Jack Leiter: 15-Day IL (ankle), Danny Jansen: 10-Day IL (forearm), Michael Helman: 60-Day IL (hand), Chris Martin: 15-Day IL (shoulder), Corey Seager: day-to-day (concussion), Carter Baumler: 60-Day IL (ribs), Cody Bradford: 60-Day IL (elbow), Jalen Beeks: 10-Day IL (back), Jordan Montgomery: 60-Day IL (elbow)

Milwaukee Brewers (48-29, first in the NL Central) vs. Cincinnati Reds (37-41, fifth in the NL Central)

Cincinnati; Wednesday, 7:10 p.m. EDT

PITCHING PROBABLES: Brewers: Shane Drohan (3-2, 3.40 ERA, 1.18 WHIP, 47 strikeouts); Reds: Rhett Lowder (3-4, 4.82 ERA, 1.45 WHIP, 42 strikeouts)

LINE: Brewers -149, Reds +122; over/under is 9 runs

BOTTOM LINE: The Cincinnati Reds are looking to stop their three-game home losing streak with a victory against the Milwaukee Brewers.

Cincinnati has a 37-41 record overall and a 19-21 record in home games. The Reds are 25-5 in games when they scored at least five runs.

Milwaukee has a 23-14 record on the road and a 48-29 record overall. Brewers hitters are batting a collective .253, which ranks fourth in the NL.

The teams meet Wednesday for the third time this season.

TOP PERFORMERS: Sal Stewart leads the Reds with 14 home runs while slugging .444. Tyler Stephenson is 11 for 34 with a double, two home runs and five RBI over the past 10 games.

Brice Turang has 11 home runs, 49 walks and 47 RBI while hitting .266 for the Brewers. William Contreras is 13 for 36 with a double, a home run and three RBI over the last 10 games.

LAST 10 GAMES: Reds: 5-5, .192 batting average, 2.80 ERA, outscored opponents by eight runs

Brewers: 6-4, .246 batting average, 2.93 ERA, outscored opponents by 13 runs

INJURIES: Reds: Nick Lodolo: day-to-day (wrist), Ke’Bryan Hayes: 10-Day IL (back), Emilio Pagan: 15-Day IL (hamstring), Graham Ashcraft: 60-Day IL (forearm), Brandon Williamson: 60-Day IL (shoulder), Hunter Greene: 60-Day IL (elbow)

Brewers: Brian Fitzpatrick: 60-Day IL (elbow), D.L. Hall: 15-Day IL (pectoral), Brandon Lockridge: 10-Day IL (knee), Quinn Priester: 60-Day IL (wrist), Carlos Rodriguez: 15-Day IL (shoulder), Coleman Crow: 15-Day IL (forearm), Jared Koenig: 15-Day IL (elbow), Logan Henderson: 15-Day IL (back), Rob Zastryzny: 15-Day IL (shoulder), Angel Zerpa: 60-Day IL (forearm)

Houston Astros (38-43, fourth in the AL West) vs. Toronto Blue Jays (39-40, third in the AL East)

Toronto; Wednesday, 7:07 p.m. EDT

PITCHING PROBABLES: Astros: Mike Burrows (3-8, 5.79 ERA, 1.58 WHIP, 66 strikeouts); Blue Jays: Trey Yesavage (3-3, 3.76 ERA, 1.16 WHIP, 53 strikeouts)

LINE: Blue Jays -163, Astros +133; over/under is 8 1/2 runs

BOTTOM LINE: Both the Toronto Blue Jays and the Houston Astros are looking for a series win with a victory on Wednesday.

Toronto is 39-40 overall and 22-19 at home. Blue Jays hitters have a collective .394 slugging percentage to rank ninth in the AL.

Houston is 38-43 overall and 18-22 in road games. The Astros have hit 107 total home runs to rank fourth in the majors.

The teams meet Wednesday for the third time this season.

TOP PERFORMERS: Ernie Clement leads the Blue Jays with a .293 batting average, and has 20 doubles, a triple, seven home runs, 10 walks and 28 RBI. George Springer is 13 for 39 with three home runs and seven RBI over the last 10 games.

Yordan Alvarez leads the Astros with 25 home runs while slugging .640. Jose Altuve is 12 for 41 with two doubles, three home runs and eight RBI over the last 10 games.

LAST 10 GAMES: Blue Jays: 6-4, .260 batting average, 4.55 ERA, outscored by seven runs

Astros: 6-4, .252 batting average, 4.20 ERA, outscored by five runs

INJURIES: Blue Jays: Addison Barger: 10-Day IL (elbow), Lenyn Sosa: 10-Day IL (wrist), Max Scherzer: 15-Day IL (back), Joe Mantiply: 60-Day IL (knee), Jose Berrios: 60-Day IL (elbow), Yimi Garcia: 60-Day IL (elbow), Cody Ponce: 60-Day IL (knee), Anthony Santander: 60-Day IL (shoulder), Bowden Francis: 60-Day IL (elbow)

Astros: LaMonte Wade: 10-Day IL (hamstring), Jeremy Pena: day-to-day (hamstring), Braden Shewmake: 10-Day IL (groin), Nick Allen: 10-Day IL (hamstring), Lance McCullers: 15-Day IL (shoulder), Bennett Sousa: 15-Day IL (elbow), Cristian Javier: 60-Day IL (shoulder), Carlos Correa: 60-Day IL (ankle), Brandon Walter: 60-Day IL (elbow), Ronel Blanco: 60-Day IL (elbow), Hayden Wesneski: 60-Day IL (elbow)

Seattle Mariners (41-39, first in the AL West) vs. Pittsburgh Pirates (39-40, fourth in the NL Central)

Pittsburgh; Wednesday, 6:40 p.m. EDT

PITCHING PROBABLES: Mariners: Bryan Woo (6-5, 3.94 ERA, 1.00 WHIP, 88 strikeouts); Pirates: Braxton Ashcraft (6-3, 3.18 ERA, 1.10 WHIP, 97 strikeouts)

LINE: Pirates -117, Mariners -104; over/under is 7 1/2 runs

BOTTOM LINE: The Seattle Mariners lead 1-0 in a three-game series with the Pittsburgh Pirates.

Pittsburgh has a 20-20 record at home and a 39-40 record overall. The Pirates rank sixth in the NL with 94 total home runs, averaging 1.2 per game.

Seattle has a 41-39 record overall and a 19-20 record on the road. The Mariners have a 26-6 record in games when they scored five or more runs.

The teams play Wednesday for the second time this season.

TOP PERFORMERS: Bryan Reynolds has 11 home runs, 50 walks and 51 RBI while hitting .287 for the Pirates. Jake Mangum is 12 for 39 with three doubles and four RBI over the past 10 games.

Julio Rodriguez leads the Mariners with 14 home runs while slugging .425. Dominic Canzone is 9 for 30 with a triple, four home runs and eight RBI over the last 10 games.

LAST 10 GAMES: Pirates: 4-6, .263 batting average, 3.83 ERA, outscored by seven runs

Mariners: 5-5, .194 batting average, 3.58 ERA, outscored by eight runs

INJURIES: Pirates: Konnor Griffin: 10-Day IL (flexor tendon), Jared Jones: day-to-day (arm), Oneil Cruz: 10-Day IL (hand), Chris Devenski: 60-Day IL (illness), Wilber Dotel: 15-Day IL (lat)

Mariners: Carlos Vargas: 60-Day IL (lat), Brendan Donovan: 10-Day IL (groin), Will Wilson: 60-Day IL (thumb), Matt Brash: 15-Day IL (lat), Cooper Criswell: 15-Day IL (shoulder), Logan Evans: 60-Day IL (arm)

Boston Red Sox (32-45, fifth in the AL East) vs. Colorado Rockies (31-49, fifth in the NL West)

Denver; Wednesday, 3:10 p.m. EDT

PITCHING PROBABLES: Red Sox: Ranger Suarez (3-3, 2.93 ERA, 1.12 WHIP, 75 strikeouts); Rockies: Kyle Freeland (1-7, 7.36 ERA, 1.58 WHIP, 57 strikeouts)

LINE: Red Sox -167, Rockies +136; over/under is 10 1/2 runs

BOTTOM LINE: The Colorado Rockies and Boston Red Sox meet on Wednesday with the three-game series tied 1-1.

Colorado has a 17-22 record in home games and a 31-49 record overall. The Rockies are ninth in the NL with 86 total home runs, averaging 1.1 per game.

Boston has a 20-20 record in road games and a 32-45 record overall. The Red Sox have the eighth-ranked team batting average in the AL at .243.

The matchup Wednesday is the third meeting between these teams this season.

TOP PERFORMERS: Troy Johnston has 22 doubles and three home runs for the Rockies. T.J. Rumfield is 13 for 40 with two doubles, a triple and four home runs over the last 10 games.

Willson Contreras leads the Red Sox with a .281 batting average, and has 12 doubles, two triples, 16 home runs, 29 walks and 45 RBI. Wilyer Abreu is 12 for 37 with three home runs and nine RBI over the past 10 games.

LAST 10 GAMES: Rockies: 5-5, .284 batting average, 4.86 ERA, outscored opponents by 10 runs

Red Sox: 4-6, .234 batting average, 3.38 ERA, even run differential

INJURIES: Rockies: Jordan Beck: 10-Day IL (hamstring), Blas Castano: 15-Day IL (pectoral), Tanner Gordon: 15-Day IL (hip), McCade Brown: 60-Day IL (shoulder), Chase Dollander: 60-Day IL (elbow), Brenton Doyle: 10-Day IL (oblique), Kris Bryant: 60-Day IL (back), Welinton Herrera: 60-Day IL (elbow), Jose Quintana: 60-Day IL (elbow), Pierson Ohl: 60-Day IL (elbow), RJ Petit: 60-Day IL (elbow)

Red Sox: Jovani Moran: 15-Day IL (elbow), Isiah Kiner-Falefa: 10-Day IL (forearm), Johan Oviedo: 60-Day IL (elbow), Triston Casas: 60-Day IL (knee), Nick Sogard: 10-Day IL (oblique), Garrett Crochet: 60-Day IL (shoulder), Romy Gonzalez: 60-Day IL (shoulder), Roman Anthony: 10-Day IL (wrist), Trevor Story: 60-Day IL (abdomen), Kutter Crawford: 60-Day IL (wrist), Patrick Sandoval: 60-Day IL (elbow), Tanner Houck: 60-Day IL (elbow)

Philadelphia Phillies (43-36, second in the NL East) vs. Washington Nationals (41-39, fourth in the NL East)

Washington; Wednesday, 6:45 p.m. EDT

PITCHING PROBABLES: Phillies: Aaron Nola (3-4, 5.71 ERA, 1.48 WHIP, 77 strikeouts); Nationals: Miles Mikolas (2-6, 5.47 ERA, 1.28 WHIP, 43 strikeouts)

LINE: Phillies -137, Nationals +113; over/under is 9 1/2 runs

BOTTOM LINE: The Washington Nationals host the Philadelphia Phillies on Wednesday.

Washington is 17-23 at home and 41-39 overall. Nationals hitters have a collective .424 slugging percentage to rank second in the NL.

Philadelphia has a 20-17 record on the road and a 43-36 record overall. The Phillies have a 31-7 record in games when they record eight or more hits.

Wednesday’s game is the sixth meeting between these teams this season. The Phillies are ahead 3-2 in the season series.

TOP PERFORMERS: Daylen Lile has 16 doubles, three triples, eight home runs and 37 RBI for the Nationals. Luis Garcia is 9 for 32 with four home runs over the last 10 games.

Kyle Schwarber leads the Phillies with 39 extra base hits (nine doubles, a triple and 29 home runs). Brandon Marsh is 12 for 43 with two doubles, three home runs and seven RBI over the last 10 games.

LAST 10 GAMES: Nationals: 6-4, .271 batting average, 4.50 ERA, outscored opponents by 11 runs

Phillies: 6-4, .287 batting average, 4.70 ERA, outscored opponents by 18 runs

INJURIES: Nationals: C.J. Abrams: day-to-day (side), Josiah Gray: 60-Day IL (elbow), Jake Irvin: 15-Day IL (shoulder), Max Kranick: 60-Day IL (elbow), Trevor Williams: 60-Day IL (elbow), Ken Waldichuk: 60-Day IL (forearm), DJ Herz: 60-Day IL (elbow)

Phillies: Kyle Schwarber: day-to-day (back), Adolis Garcia: 60-Day IL (lat), Brad Keller: 15-Day IL (forearm)